Lorazepam Anxiolytic Drug


Lorazepam is an anxiolytic drug belongs to benzodiazepines. Anxiolytic drugs, including Lorazepam inhibit the action of central nervous system (CNS), mainly in thalamus, hypothalamus and limbic system.

Lorazepam increases the release of gamma-aminobutyric acid (GABA), which is one of the main mediators that inhibit nerve impulses transmission in the CNS. Lorazepam possesses anxiolytic, hypnotic, sedative, muscle relaxant and anticonvulsant effects.

Mechanism of Lorazepam action is to stimulate benzodiazepine receptors that:activate GABA receptors;reduce the excitability of the subcortical brain structures;slow down polysynaptic spinal reflexes.

After oral administration, Lorazepam drug is slowly but completely absorbed from the gastrointestinal tract. Maximum concentration in the plasma is achieved about 2 hours after a single daily dose of Lorazepam 2mg. Equilibrium concentration of Lorazepam pills in the plasma is achieved 24-36 hours after oral use.

Half-life of Lorazepam from the body is approximately 20 hours. Lorazepam drug is quickly excreted from the body after the withdrawal. Lorazepam pharmacokinetics in elderly patients (over 65 years) corresponds to Lorazepam pharmacokinetics in patients of middle age. Since Lorazepam is metabolized mainly by kidneys, patients with kidney dysfunction are recommended to take Lorazepam with caution.

Lorazepam use

Lorazepam drug is prescribed for:
treatment of neurosis and neurotic disorders, including depression, accompanied by anxiety and sleep disorders;
premedication, used one night and (or) 1-2 hours before surgery.

Lorazepam provides sedative action, reduces neurosis and depressive symptoms, normalizes a patient’s general state and sleep.

Contraindications to Lorazepam use

Lorazepam drug is contraindicated in: hypersensitivity to benzodiazepine derivatives; chronic obstructive pulmonary disease, respiratory failure, obstructive sleep apnea; as well as in children (under 12 years); during pregnancy and breastfeeding.

Lorazepam side effects

As any other medication Lorazepam drug has side effects. Lorazepam side effects are weakly pronounced and quickly disappear. Lorazepam side effects may include: dizziness; anxiety; sleep disorder; smooth muscles spasm; increased sweating; nausea; vomiting; tremor; perceptual disorders; photophobia; skin rash and itching.

You could have unpleasant side effects if you stop using Lorazepam suddenly. In this case, Lorazepam side effect are more clearly pronounced and are able to harm patient’s health.

Lorazepam drug interactions

Lorazepam effect on CNS functions increases in simultaneous use with sedatives, tricyclic antidepressants, non-selective MAO inhibitors, muscle relaxants, analgesics, phenothiazines and other neuroleptics.

Lorazepam plasma concentration increases in combination with cimetidine, disulfiram, erythromycin, fluoxetine, as well as with oral contraceptives and drugs that inhibit liver metabolism.

Lorazepam concentration in the plasma decreases in simultaneous use with rifampicin.

Lorazepam activity decreases in simultaneous use with MAO inhibitors, respiratory analeptics and psychostimulants.

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